Drug Discovery Research Project on KRAS G12C

In order to strengthen your profile so to have better opportunities in your career, i. e, for jobs or for higher studies you need to have good publications under your belt. The only program since 2010 which is fulfilling this need is the Research Project Training Program of BDG LifeSciences which is of novel research projects on the latest technologies of Bioinformatics.

In this program, we implement the current research trend and apply unique ways of teaching plus practical application so to make you learn in the best possible way. As it is done online hence participants have the freedom of choosing the time of training sessions according to their choice and also save a huge amount of money in travel, accommodation, food, etc., As of now we have completed more than 85 research projects and all of them published at International level. This research project can be done as a Major and/or thesis project for the final year or if someone wants to strengthen their profile.

Applications are invited for 4 seats in our 91 novel research project entitled "Computational Study of Veratrum dahuricum derived compounds against KRAS G12C: Virtual Screening, Molecular Docking, ADMET Profiling, and MD Simulations for Antitumor Drug Discovery"

This research project focuses on using computational methods to explore anticancer agents from Veratrum dahuricum as potential selective inhibitors for KRAS G12C, specifically targeting their application in treating non-small cell lung cancers (NSCLC), colorectal cancers, and other solid tumors. The study employs virtual screening and molecular docking techniques to identify promising compounds that can selectively inhibit the activity of KRAS G12C.

• Introduction of Drug Discovery

• Science involved in disease target identification

• Virtual Screening

• In-silico generation of novel ligands- Molecular Editing

• Conversion of files- .mol to .pdb

• Protein Optimization

• Energy Minimization

• Molecular Docking- Creation of .gpf and .dpf files

• Algorithm-autogrid&autodock

• Selection of inhibitors on the basis of delta G.

• Structure Analysis/ H-bond/Atomic-level studies

• Prediction of Molecular Properties

• Prediction of Bioactivity

• ADMET- Bioavailability-LD 50-AMES Test, etc

• Drug Likeness

• MD Simulations 

SYSTEM REQUIREMENT: Windows OS with 10th generation or above and i3 processor or above with internet

ELIGIBILITY: Anyone who is a UNDERGRADUATE/GRADUATE or HIGHER DEGREE is the minimum requirement to register for this project. This project is strictly not for HIGH SCHOOL (Class 9 & 10) / COLLEGE (Class 11 & 12) students. For them we have other projects which can be presented in Science Fair.

• Training in Drug Discovery & Designing.

• Opportunity to work on a novel research project.

• Practical application of training

• Software, which you can use for other projects.

• Tutorial and Papers of technology., so to make you understand every aspect of the technology.

• Chance of getting it published at an International Conference/Journal.

• Certificate of Training in Research Project.

• Recommendation letter for Job/PhD.

• Add the position of Research Project Trainee in your CV and LinkedIn profile. This will serve the purpose of work experience.

• We will connect you with people in our group who did projects with us which will help you in getting jobs as well as PhD positions around the world.

• Once you register and pay the fee we will send you a welcome email having details.

• Once registration is done it is NON-REFUNDABLE/NON TRANSFERABLE.

• While you will be working on the project and completing the tasks to monitor the progress of your work you have to send daily project reports to your guide.

• You will be directly connected to your guide as well as in a group where people who have completed their research project with us are present to solve your queries at the earliest.