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The study and research of psilocybin began in the 1940s as a psychedelic medicine to treat various psychiatric conditions such as depression, substance use disorders, and alcohol use disorders. All research and clinical use of psilocybin was shut down in the 1970s after it was declared a Schedule I drug, ultimately becoming illegal.
“There are misconceptions of psychedelics, what they do or don’t do, and what the risks are,” Lewis says. One of these misconceptions is the potential for abuse of psychedelic drugs. “Classic psychedelics like psilocybin or LSD don’t really have abuse potential in the same fashion as other drugs like alcohol, nicotine, cocaine, and opioids,” Lewis says.
It wasn’t until recently—in the last ten years—that new research has looked into psilocybin and other psychedelics as potential mental health treatments. A recent study from Johns Hopkins showed that psychedelic treatment with psilocybin relieved major depressive disorder symptoms for patients for up to a month.
“There’s a lot of promise based on early studies, but those studies to date have been pretty small and limited in certain regards,” Lewis says.
Some of these research studies have looked at psilocybin as treatment for major depressive disorder and for treatment-resistant depression. While the studies are promising, Lewis says these studies are small, have limitations, and involved participants that are extensively screened and monitored through the process.
While research of psilocybin is ongoing, data to date have shown promising results in treatment of:
Major depressive disorder
Treatment resistant depression
Alcohol use disorder
Anxiety at end of life, or existential distress
Tobacco use disorder
OCD
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