Drug Discovery Project on Tuberculosis

In order to strengthen your profile so to have better opportunities in your career, i. e, for jobs or for higher studies you need to have good publications under your belt. The only program since 2010 which is fulfilling this need is the Research Project Training Program of BDG LifeSciences which is of novel research projects on the latest technologies of Bioinformatics.

In this program, we implement the current research trend and apply unique ways of teaching plus practical application so to make you learn in the best possible way. As it is done online hence participants have the freedom of choosing the time of training sessions according to their choice and also save a huge amount of money in travel, accommodation, food, etc., As of now we have completed more than 70 research projects and all of them published at International level. This research project can be done as a Major and/or thesis project for the final year or if someone wants to strengthen their profile.

CURRENT RESEARCH PROJECT FOR INTERNSHIP
Applications are invited for 5 SEATS in our 85 novel research project entitled "Molecular Modeling study of derivatives of Leaf Extracts of medicinal plant Solanum torvum and Serine/Threonine Kinase from Mycobacterium Tuberculosis"

DURATION

2-3 Months- training sessions will be conducted online according to the date and time you choose.

Topics which will be covered:

• Introduction to computer-aided drug designing
• Ligand based drug designing
• Structure-based drug designing
• Molecular Docking
• Molecular Dynamics Simulation

PART 1- Molecular Docking with practical application on Windows

Installation of software [ADT,DSV,PYMOL,CHIMERA,AUTODOCK VINA,PyRx]

Minimization of protein and ligand.

Preparation of files.

Grid box preparation.

Command execution.

Visualization and analysis of results.

Installation of PyRx.

Site specific docking with PyRx.

Visualization and analysis of results.

PART 2- Molecular Dynamics Simulation- Protein-ligand complex simulation using GROMACS on Virtual Box

Installation of virtual box

Installation of software

Preparation of protein topology

Preparation of ligand topology

Preparation of complex gro file

Solvation

Ionization

Minimization

Making index files

Equilibration phase 1[NPT]

Equilibration phase 2[NVT]

Final production MD run

VMD and QTGRACE/XMGRACE analysis with universal codes [RMSD,RMSF, HBONDS, ENERGY, RADIUS OF GYRATION]

PRACTICAL APPLICATION- TOOLS ON WHICH YOU WILL WORK ON YOUR COMPUTER SYSTEM

AUTODOCK TOOLS

AUTODOCK VINA

CHIMERA

PYRX

PYMOL

DISCOVERY STUDIO VISUALIZER

GROMACS

SWISSPARAM

VMD

QTGRACE

XMGRACE

SYSTEM REQUIREMENT: Windows OS with 10th generation or above and i3 processor or above with internet

PROBABLE OUTCOME

At the end of the study we would be able to get molecules that would show the best binding affinity to the biological target as well as ready to be checked for further PK/PD studies. After the successful completion of the project, it will be submitted for international publication by the names of people who will work on this project.

WHAT YOU GET

• Training in Drug Discovery & Designing. Opportunity to work on a novel research project. Practical application of training.
  Software, which you can use for other projects.
• Tutorial and Papers of technology. So to make you understand every aspect of the technology.
• Publication of the project by your name at International Level in the form of Paper/ Oral/ Poster/ Abstract.
• Certificates of Training & Research Project.
• Recommendation letter for Job/PhD.
• Add the position of Research Project Trainee in your CV and LinkedIn profile. This will serve the purpose of work experience.
• We will connect you with people in our group who did projects with us which will help you in getting jobs as well as PhD positions around the world.

T & C

• Only Windows OS is required for training & software installation.
• Once you register and pay the fee we will send you a welcome email having details to prepare your system and installation of the software. Information of molecules (dataset of molecules) on which you have to work. Files and papers of technology as well as of project.
• Once registration is done it is NON-REFUNDABLE/NON TRANSFERABLE.
• Once you prepare your system and tell us when to conduct your training session and do not turn up then we will send you the steps of that phase.
• The certificate will be given only when you complete all the tasks of the project, which means 5 phases.
• While you will be working on the project and completing the tasks to monitor the progress of your work you have to send daily project reports to your guide.
• You will be directly connected to your guide as well as in a group where people who have completed their research project with us are present to solve your queries as the earliest.