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It is safe to provide oxycodone together with over-the-counter pain relievers such as paracetamol (Panadol) and anti-inflammatory drugs (Nurofen). It can be hazardous to consume alcohol or other drowsy medications (such as prescription cough medications, sleep aids, and other potent painkillers) while using oxycodone. While taking oxycodone, no medication containing morphine or codeine should be administered to you.